English Views: 75 Author: Site Editor Publish Time: 2022-08-08 Origin: Site
Aerosol means that the medicine, emulsion or suspension is encapsulated in a pressure-resistant aerosol filling machine with a special valve system together with a suitable propellant, and the content is sprayed into a mist by the pressure of the propellant. It is used for pulmonary inhalation or directly sprayed to the mucous membrane of the cavity, skin and space for disinfection.
What are the different types of aerosols according to the route of administration?
What is the role of aerosol machine?
What are the regulations regarding the use of aerosol machines?
(1) Inhalation aerosol: refers to a drug-containing solution, suspension or emulsion, which is packaged together with a suitable propellant or liquefied mixed propellant in an aerosol filling machine with a quantitative valve system and a certain pressure. The pressure of the propellant, the content is sprayed out in the form of a mist, and the preparation deposited in the lungs is inhaled by mouth, also commonly known as pressure metered dose inhaler. Pressing the valve can release the active substance quantitatively, and the drug is dispersed into particles or mist droplets, which can be inhaled through the respiratory tract to exert local or systemic therapeutic effects.
(2) Non-inhalation aerosols: such as aerosols for skin and mucous membranes. Skin aerosols are mainly used for wound protection, cleaning and disinfection, local anesthesia and hemostasis. Nasal aerosols refer to formulations deposited into the nasal cavity by nasal inhalation. Nasal mucosal aerosols are used in the administration of some protein and polypeptide drugs and can exert systemic effects. O/W foam aerosols are commonly used in vaginal mucosal aerosols, which are mainly used to treat vaginitis caused by microorganisms and parasites, and can also be used for birth control.
(3) External aerosols: refers to aerosols used for skin and space disinfection.
Aerosols stored in the aerosol machine can be used for local or systemic therapeutic effects. Local therapeutic effects such as: Yansukang aerosol for the treatment of pharyngitis, compound naphazoline spray for the treatment of rhinitis, compound metronidazole aerosol for the treatment of vaginitis, local anesthesia and analgesic lidocaine aerosol, etc.; Systemic therapeutic effects such as: glucocorticoid budesonide aerosol, anti-angina pectoris nitroglycerin aerosol, antipyretic and analgesic indomethacin aerosol, etc.
1. Aerosols should be prepared in a clean, germ-free environment. Various utensils, containers, etc. must be cleaned and sterilized by appropriate methods. Care should be taken to prevent microbial contamination throughout the operation.
2. When using the aerosol machine to prepare aerosols, an appropriate amount of antioxidants or bacteriostatic agents can be added according to the nature of the drug. Inhalation aerosols, aerosols for skin and mucous membranes should have no adverse irritation.
3. The fineness of the mist or drug particles for inhaling aerosols should be controlled under 10 μm, and most of the particles should be less than 5 μm.
Yangzhou Meida Filling Machinery Co.,Ltd has focused on the development and production of aerosol machines for several years. And it commits to provide perfect service for every customer from all over the world.
